Endocrine Abstracts

Introduction: 48, XXYY is a rare sex chromosome aneuploidy, being estimated to occur in 1:18000–1:40000 male births. Phenotypically it was considered a variant of Klinefelter syndrome (47,XXY), but currently, due to mental deficiency and behavioural characteristics associated, it’s considered to be a separated genetic condition.Case report: We report a case of a 8-year-old boy, first child of a young non-consanguineous couple, born at term. Due...

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor derived from the thyroid C cells producing calcitonin, ac-counts for 0.6% of all thyroid cancers. It occurs either sporadically or in a hereditary form (RET mutation). MTC can be cured only by complete resection of the thyroid tumor and any loco-regional metastases. Calcitonin (CT) measurement is crucial to the early diagnosis and the follow-up of MTC. If the evaluation of stimulated CT levels is required, a prov...

Abstract: Medullary thyroid cancer (MTC) is a highly aggressive neuroendocrine tumour originating in the thyroid parafollicular cells. Calcitonin measurement and RET gene ascertainment have been used as markers for early diagnosis of MTC. Since pentagastrin is not available, calcium stimulation test helps to preclude ‘gray zone’ values of basal calcitonin, diagnose minimal residual disease and help the early diagnosis of C cell hyperplasia.Aim:...

Introduction: Agonist receptor-GLP1 (AR-GLP1) had demonstrated its utility in obese patients with diabetes type 2. Since August 2013 we have available in Spain a new AR-GLP1 with prandial action in a single daily dose, lixisenatide. There are different clinical trials that support its efficacy and security but the dates from real clinical practice are scarce.Aim: To analyse the efficacy and security in real clinical practice for the treatment of diabetic...

Introduction: As antipsychotic drugs specifically block the D2 receptors, they induce a certain level of prolactin increase, dependent on the time it takes to dissociate from receptors. A recent review (Besnard et al, 2013) mentions that 18% of men and 47% of women treated with antipsychotics for severe mental illness had an increased prolactin level. Even if the long term effects of hyperprolactinemia can be severe, including low bone density, amenorrhea, breast and ...

Epidemiological studies have shown that plasma SHBG levels correlate with plasma adiponectin levels, both in men and women. To the best of our knowledge there are no reports describing any molecular mechanism by which adiponectin regulates hepatic SHBG production. The aim of the present study is to explore whether adiponectin regulates SHBG production by increasing HNF-4α levels through reducing hepatic lipid content. For this purpose, in vitro studies using huma...

Introduction: Uric acid may increase cardiovascular risk, exerting proinflammatory, pro-oxidant and proliferative actions at the endothelial cell level. Classic and non-classic cardiovascular risk markers cluster in women with polycystic ovary syndrome (PCOS), uric acid being proposed as one of them. The studies available at present regarding serum uric acid levels in PCOS patients are scarce and controversial. The aim of the study was to examine the relationship between uric ...

GH deficiency (GHD) in adults is characterized by a tendency towards fat mass gain and may predispose to type 2 diabetes mellitus.GH replacement (GHR) is associated with impaired insulin sensitivity shortly after starting therapy, reflected by increased fasting glucose and insulin levels. Available evidence suggests that concerns regarding glucose intolerance in patients receiving long-term GHR have not been substantiated. However, several environmental and lifestyle-related f...

Introduction: Although for the last 2 decades we have witnessed a rise in the use of second generation antipsychotic treatment in children and adolescents suffering from psychiatric disorders we do not have enough studies in specialty literature to estimate the risks associated with this medication. Recent data and also our clinical experience shows that second generation antipsychotic drugs administration correlates with considerable weight gain and also with altering of gluc...

Growth hormone deficiency leads to profoundly decreased growth velocity and, when untreated, to pituitary dwarfism. We evaluated growth evolution for one to four years under rGH therapy (0.07 IU/kg/day, subcutaneously) at seventeen idiopathic pituitary dwarves with isolated GH deficiency, 13 boys and 4 girls, with a wide span of age at therapy onset (between 4 and 24 years old). Diagnosis was set subsequent to at least two negative GH stimulation tests. All patients were pre-p...